Because lupus is an autoimmune disease that affects the collagen tissue in the entire body, the collagen component of the mucosa of the mouth, including the gingival tissue and salivary glands also present the symptoms seen elsewhere in the body. A person with lupus demonstrates increased levels of xerosthemia or dry mouth leading to increased levels of caries, periodontitis and candidiasis. Plaquenil birth defects Plaquenil menstruation disturbance Drug induced gingival hyperplasia can be caused by cyclosporine and calcium channel blockers. Angioedema of the lip can be a secondary reaction to ACE-inhibitors. ACE-inhibitors are used to treat hypertension. This reaction can also be a result of anti-seizure medications and immune-suppressants. Gingival enlargement is an increase in the size of the gingiva. It is a common feature of gingival disease. Gingival enlargement can be caused by a number of factors, including inflammatory conditions and the side effects of certain medications. The treatment is based on the cause. A closely related term is epulis, denoting a localized tumor on the gingiva. Dec 05, 2019 Frequency not reported Gastrointestinal disorder, gingivitis, gingival hyperplasia. Dermatologic. Well-documented cases of rashes as leukocytoclastic vasculitis have been reported, but a definitive between these events and this drug have not been established. Lichenoid keratosis and hyperpigmentation occurred in skin exposed to the sun. What are called leukoplakic lesions (white scaly tissue detaching from the underlying tissue) can appear on the skin or mucosa of the cheek, palate, o r vermillion border of the lips. The gingival tissue may become red and appear to be desquamating. Hydroxychloroquine gingival hyperplasia Disease-modifying Anti-rheumatic Drugs DMARDs for., Gingival enlargement - Wikipedia Terrien's marginal degeneration plaquenil Profile. Definition Gingival hyperplasia is defined as an enlargement of the gingiva that is noninflammatory, produced by factors other than local irritation, and the result of an increased number of cells. 1 Because gingival hyperplasia denotes a specific histologic diagnosis, clinicians must rule out other causes of gingival enlargement with biopsies of affected tissues. 2 A common example. Gingival Hyperplasia Clinician's Brief. Diltiazem Side Effects Common, Severe, Long Term -. Cyclosporin A a new drug in the field of canine dermatology.. Gingival hyperplasia from phenytoin. The mechanisms of adverse reactions to drugs vary. Some, like the urticarial or eczematous, are clearly based on an allergic or immunologic mechanism; others are utterly obscure in mechanism. Such is the gingival hyperplasia caused by phenytoin. Side Effects. Drug information provided by IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis.