Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Malaria chemoprophylaxis chloroquine phosphate tablet 500 mg Plaquenil cognitive side effects Chloroquine how effective against malaria Hydroxychloroquine, on the other hand, is much less toxic to the retina and there have been fewer reported eye problems. In general, a baseline ophthalmic examination should be performed upon initiation of therapy. In addition, a central visual field test and color photographs of the retina are usually taken at that time. Plaquenil is the one drug that you need the eye exam prior to starting the drug as they really need that baseline. If it's going to affect your eyes, tends to do so in the first 6 months. but I don't think MTX is the same.doc hasn't made me get it prior to treatment but he is adamant about yearly eye exams. May 24, 2019 If you are allergic to hydroxychloroquine; any part of hydroxychloroquine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you have had any eye changes or changes in eyesight due to hydroxychloroquine or drugs like this one. If you have psoriasis. If you have porphyria. If you are taking cimetidine. If you are taking any drugs that can cause a certain type of heartbeat that is not normal prolonged QT interval. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Do you need a baseline eye exam before taking hydroxychloroquine Plaquenil -, Bone Joint Muscle - Arthritis Baseline eye exam and Methotrexate Hydroxychloroquine dosesHydroxychloroquine sulfate brand name in indiaChloroquine over the counter ukHydroxychloroquine medscape May 24, 2017 As I mentioned before, hydroxychloroquine eye toxicity is not reversible. Once it happens, it happens. So the trick is to catch it early. Fortunately, the changes occur VERY slowly. The American Academy of Ophthalmology recommends the following Obtain a baseline eye exam within the first year of starting hydroxychloroquine to document any complicating eye problem. Will hydroxychloroquine hurt my eyes? - RheumDoctor. Hydroxychloroquine Indications, Side Effects, Warnings.. My Take on New Ocular Screening Guidelines for Plaquenil.. Otherwise, you should have a check up with an optician once a year and tell them that you're taking hydroxychloroquine. You should report any new eye symptoms to your doctor straight away. If you develop any other new symptoms or there's anything else that concerns you after starting hydroxychloroquine, you should tell your doctor or rheumatology nurse specialist as soon as possible. Aug 29, 2014 As a precaution, patients treated with Plaquenil are advised to get a baseline eye exam prior to starting the drug and then annually thereafter. This information provided by Neil I. Stahl, MD & Tongalp H. Tezel, MD was first printed in the The Moisture Seeker, SSF's patient newsletter for members. Aug 30, 2011 Newer guidelines state that daily dose 5mg/kg of real weight/day can lead to toxicity. Retinal toxicity is irreversible and can progress after cessation of hydroxychloroquine, thus early screening is important to limit potential vision loss. Baseline screening and annual screening after five years is recommended.