Chloroquine administration

Discussion in 'Plaquenil Generic' started by Strekoza, 15-Mar-2020.

  1. paraplan Well-Known Member

    Chloroquine administration


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine Phosphate Tablets are an antimalarial and amebicidal drug. Each tablet, for oral administration, contains 250 mg chloroquine phosphate equivalent to 150 mg base or 500 mg chloroquine phosphate equivalent to 300 mg base. Luchters SMF, Veldhuijzen NJ, Nsanzabera D. et al. A phase I/II randomised placebo controlled study to evaluate chloroquine administration to reduce HIV-1 RNA in breast milk in an HIV-1 infected breastfeeding population the CHARGE Study. XV International Conference on AIDS; Bangkok, Thailand; July 11–16, 2004. Abstract TuPeB4499.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine administration

    WHO Model Prescribing Information Drugs Used in Parasitic Diseases., CHLOROQUINE PHOSPHATE TABLETS, USP 250 MG and 500 MG

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  7. Indications and Administration. Chloroquine is the drug of choice in the few malaria-endemic areas free of CRPf. Combining chloroquine and proguanil is an option for CRPf when other first-line antimalarials are contraindicated. Dosage should be calculated in terms of the base.

    • Chloroquine - an overview ScienceDirect Topics.
    • New insights into the antiviral effects of chloroquine..
    • Chloroquine Indications, Side Effects, Warnings -.

    Aralen, chloroquine phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble in water. Aralen is an antimalarial and amebicidal drug. Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best. The results of concurrent chloroquine and ethanol administration showed that there is an increase in kidney weight and renal hypertrophy with compromised renal function indicated by the decrease in renal maximum urine concentrating ability and an increase in the serum creatinine level.

     
  8. Zarub New Member

    Mixed connective tissue disease commonly abbreviated as MCTD, is an autoimmune disease characterized by the presence of elevated blood levels of a specific autoantibody, now called anti-U1 ribonucleoprotein (RNP) together with a mix of symptoms of systemic lupus erythematosus (SLE), scleroderma, and polymyositis. Mixed Connective Tissue Disease Symptoms, Causes, and. Mixed Connective Tissue Disease MCTD - Bone, Joint, and. What Is Undifferentiated Connective Tissue Disease?
     
  9. AlexLen User

    The following protocol is for 10 cm dish (medium: 10ml). High efficiency polyoma DNA transfection of chloroquine. Facile Construction of Chloroquine Containing PLGA-Based pDNA Delivery. Calcium phosphate–mediated transfection of eukaryotic.
     
  10. metadon.info XenForo Moderator

    G6PD and Malaria – In some cases, yes. When a patient has been diagnosed with Plasmodium ovale or Plasmodium vivax infection, in addition to medication such as chloroquine to target the blood stages of the parasite, an additional drug, called primaquine, may also be required. Primaquine kills the liver stages, known as hypnozoites, of these forms of malaria.

    The DETECTIVE trial tafenoquine reduces risk of Plasmodium vivax.
     
  11. teloZVER Moderator

    Hydroxychloroquine and the immune system Hi everyone. Hydroxychloroquine and the immune system. But do look after yourself, and make sure you eat well and don't get too tired as if you have a cold already you need to pamper yourself a bit more than you would have before RA. Polly. Hydroxychloroquine; Supporting the community See all. Eleanor-NRAS Administrator.

    Hydroxychloroquine Oral Uses, Side Effects, Interactions.