Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine resistant malaria in pregnant Hydroxychloroquine quinine Chloroquine is not active against the gametocytes and the exoerythrocytic forms including the hypnozoite stage P. vivax and P. ovale of the Plasmodium parasites. In vitro studies with Chloroquine demonstrated that it is active against the trophozoites of Entamoeba histolytica. Chloroquine A drug used against malaria for both prevention and treatment. A very safe and inexpensive drug, its value has been compromised by the emergence of chloroquine-resistant malaria parasites. Cinchonism Side effects from quinine or quinidine. Includes tinnitus, headache, nausea, diarrhea, altered auditory acuity, and blurred vision. An antimalarial agent used for the treatment and suppression of Plasmodium vivax, P. malariae, and P. falciparum; available in phosphate and sulfate forms. It does not produce a radical cure because it has no effect on the exoerythrocytic stages; chloroquine-resistant strains of P. falciparum have developed in Southeast Asia, Africa, and South America. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine exoerythrocytic Exoerythrocytic definition of exoerythrocytic by Medical., CDC - Malaria - Glossary Hydroxychloroquine surfactant protein c deficiencyHydroxychloroquine and platelets Chloroquine is active against the erthyrocytic forms of Plasmodium vivax, Plasmodium malariae, and susceptible strains of Plasmodium falciparum but not the gametocytes of P. falciparum. It is not effective against exoerythrocytic forms of the parasite. Chloroquine West-ward Pharmaceutical Corp FDA Package.. Chloroquine definition of chloroquine by Medical dictionary. Primaquine Phosphate Tablets Uses, Dosage, Side Effects.. CLINICAL PHARMACOLOGY Primaquine phosphate is an 8-amino-quinoline compound which eliminates tissue exoerythrocytic infection. Thereby, it prevents the development of the blood erythrocytic forms of the parasite which are responsible for relapses in vivax malaria. Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase. Chloroquine Phosphate Tablets are an antimalarial and amebicidal drug. Each tablet, for oral administration, contains 250 mg chloroquine phosphate equivalent to 150 mg base or 500 mg chloroquine phosphate equivalent to 300 mg base.