It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Plaquenil overdose treatment Drug of choice for chloroquine resistant malaria Plaquenil generic goodrx Your weakness sounds really severe and I agree it really needs to be looked into. I have muscle weakness that is especially bad during flares, but not as bad as yours. I have a hard time holding my arms up for very long when this happens which makes it hard to wash or blow dry my hair. I also can't walk too far without my legs burning. What is Plaquenil? Plaquenil hydroxychloroquine is a medication most known for its original purpose of treating or preventing malaria, a disease caused by parasites that enter the body through the bite of a mosquito. The leg weakness was one of my first "ah ha" symptoms that took me to the doctor for my dx. I was going to the gym every day for weeks, and before that I would run at home. Then I got what I thought was a virus. Finally feeling a little better, I went to the mall. And out of the blue, I had extreme weakness- in my hands, arms, and then in my legs. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil leg weakness Symptoms and causes of muscle weakness STIWELL, Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Treating psoriatic arthritis with plaquenilCan chloroquine abort pregnancy Hi. I have been on plaquenil for about 3 years now. I walk my dogs 4 miles a day and have always been active. For the past year, My legs have become progressively weak and tired all the time. It is difficult to climb one flight of stairs let alone a small hill. My PCP ruled out a vascular problem and said it is probably the plaquenil. Hydroxychloroquine - thigh muscle weakness?. Leg weakness? - Sjogren's World. Leg Pain and Numbness What Might These Symptoms Mean?. Numbness and tingling is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 1 month, also take medication Aredia, and have Osteoporosis Plaquenil; Descriptions. Check with your doctor right away if you have muscle weakness, pain, or tenderness while using this medicine. Wear long-sleeved shirts or blouses and long trousers to protect your arms and legs, especially from dusk through dawn when mosquitoes are out. It doesn't mean I don't have any muscle weakness from the scleroderma, but the crazy, out-of-control weakness was from Plaquenil. Theoretically it only happens in 1 in 1000 cases hence being called a "zebra" and my experienced neurologist had never had a case due to Plaquenil before statins, yes - but not Plaquenil.