Ophthalmic surveillance was performed on patients in a multicenter clinical trial testing high-dose (1000 mg daily) hydroxychloroquine for advanced non–small cell lung cancer. The US Food & Drug Administration–recommended screening protocol included only visual acuity testing, dilated fundus examination, Amsler grid testing, and color vision testing. Chloroquine & Hydroxychloroquine patient reviews Quinine chloroquine side effects Acute zonal occult outer retinopathy AZOOR is a retinal disease first described by Gass in 1992; reporting on 13 cases that shared the following features rapid loss of one or more large zones of outer retinal function, minimal fundus changes, electroretinographic abnormalities, and permanent visual field loss that was associated with delayed development of visible atrophic changes in the. Irreversible retinopathy and ototoxicity can result from high daily doses 250 mg of chloroquine or HCQ that lead to cumulative total doses of more than 1 g of base per kilogram body weight 97–99. Retinopathy presumably is related to drug accumulation in melanin-rich tissues and can be avoided if the daily dose is 250 mg or less. Autoimmune retinopathy associated with systemic lupus erythematosus A diagnostic dilemma. Taiwan J Ophthalmol 2017;2-6. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the Out of the 7 patients having exposure of at least 6 months, 2 developed retinal toxicity (at 11 and 17 months of exposure). In patients seen at Stanford, additional sensitive screening procedures were added at the discretion of the retinal physician: high-resolution spectral-domain optical coherence tomography (OCT), fundus autofluorescence (FAF) imaging, Humphrey visual field (HVF) testing, and multifocal electroretinography (mf ERG). Hydroxychloroquine-mediated retinopathy Chloroquine analogues in drug discovery new directions of., Hydroxychloroquine From Malaria to Autoimmunity SpringerLink Rash with hydroxychloroquineHow do i stop taking plaquenil Autoimmune retinopathy AIR is a rare and still poorly understood immune-mediated disease that may cause inflammation from circulating autoantibodies against the retina. It may be related to history of autoimmune disease in the patient or in a family member or the presence of neoplastic disease in the individual. The disease may be subdivided into paraneoplastic and non-paraneoplastic AIR. Autoimmune retinopathy A Review International Journal of.. Autoimmune retinopathy associated - Digital Commons. Genetic Variants in Egyptian Patients Receiving HCQ.. Megan B. Goodman, Ari Ziskind, Fundus auto fluorescence and spectral domain ocular coherence tomography in the early detection of chloroquine retinopathy, African Vision and Eye Health, 2015, 74, 1CrossRef; 19 Junyeop Lee, Joo Yong Lee, Hydroxychloroquine Retinopathy, Journal of Rheumatic Diseases, 2015, 22, 3, 140CrossRef In patients with systemic lupus erythematosus SLE, hydroxychloroquine prevents disease flares and damage accrual and facilitates the response to mycophenolate mofetil in those with renal involvement. A study was undertaken to determine whether hydroxychloroquine also exerts a protective effect on survival. Most cases of chloroquine retinopathy have developed when a higher than currently recommended 3 mg/kg/day using lean body weight dose was used. 21 A daily dose exceeding 250 mg with a total cumulative dose between 100 and 300 g is customarily needed to produce toxicity. 22 One study showed a 19% incidence of chloroquine retinopathy in.