Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Vitamin c and plaquenil Hydroxychloroquine tablets ip 400 mg The only side effects related with taking a large amount of melatonin are continued drowsiness and a slower reaction time. Many people are discouraged from taking melatonin. People with the symptoms of severe mental illness, severe allergies, auto-immune diseases. The study is based on hydroxychloroquine sulfate and melatonin the active ingredients of Plaquenil and Melatonin, respectively, and Plaquenil and Melatonin the brand names. Other drugs that have the same active ingredients e.g. generic drugs are not considered. Take hydroxychloroquine with a meal or a glass of milk. To prevent malaria Start taking the medicine 2 weeks before entering an area where malaria is common. Continue taking the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Taking melatonin with hydroxychloroquine Hydroxychloroquine Plaquenil Side Effects & Dosage for., Plaquenil and Melatonin drug interactions - eHealthMe Hydroxychloroquine in breastfeeding If you are also taking a certain drug for diarrhea kaolin or taking antacids such as magnesium/aluminum hydroxide, take hydroxychloroquine at least 4 hours before or after these products. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Hydroxychloroquine - Side Effects, Dosage, Interactions.. Melatonin - Mayo Clinic. WebMD provides information about interactions between Calcium-Melatonin Oral and di-trivalent-cations-chloroquine-hydroxychloroquine. I take 10mg Ambien and split it in half and if I don't take it before 10 at night then I won't wake up in the morning. But melatonin, I use 10mg melatonin if it's too late to take my ambien and I've never had trouble waking up in the morning after taking that. Sometimes I take 2 10mg to make myself pass out. Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis.