People who have this virus and take certain disease-modifying medications for MS may be at risk for a rare, yet serious, disease. The disease is called progressive multifocal leukoencephalopathy (PML). Aralen phosphate side effects Plaquenil and hydroxychloroquine Plaquenil and drinking alcohol The biology of MS. Peripheral nervous system. While the central nervous system CNS is composed of the nerves of the brain and the spinal cord, the peripheral nervous system PNS describes all the nerves that serve the sensory organs, muscles, glands, and other parts of the body outside the brain and spinal cord. JC virus is a widespread pathogen in human populations. Although it is recognized as the cause of PML, simple infection with the virus does not result in CNS disease. PML occurs exclusively in patients with primary or secondary immunosuppression and is caused by activation of a virus already present in the brain as a consequence of prolonged. There is often alarm and confusion about the JC virus, how we get it, and what it means to people with multiple sclerosis. This is my quick primer to help address these questions in a very basic way. In MS, it is the loss of myelin that damages nerve function. It results when JC virus infects oligodendrocytes, cells that insulate nerve cells with myelin. Jc virus and plaquenil Plaquenil Uses, Dosage & Side Effects -, Progressive multifocal leukoencephalopathy in systemic. Hydroxychloroquine and stomach painMalaria drug hydroxychloroquine JC virus can cause the serious neurological disease progressive multifocal leukoencephalopathy PML in patients who are immunocompromised. Presence of JC virus antibodies alone is not enough to diagnose PML, however, because the majority of adults who have been exposed to the virus don’t develop symptoms JC Virus What Is It, and How Should I Test for IT?. MS and the JC Virus A Primer to Understanding Its Scope. JC virus symptoms, treatments & forums PatientsLikeMe. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Chloroquine is a 9-aminoquinoline that has been known since 1934. Specifically synthesised to be used as an antimalarial agent, chloroquine was subsequently shown to have immunomodulatory properties that have encouraged its application in the treatment of autoimmune diseases such as rheumatoid arthritis. Several members of mosquito-born flaviviruses, such as dengue virus serotype 1–4 DENV-1-4, yellow fever virus YFV, West Nile virus WNV, and Japanese encephalitis virus JEV, are highly pathogenic to humans and these infections have become major international health problems Seligman and Gould 2008.