This medicine is also sometimes given off-label to help the following conditions: Also, let your doctor know if you drink large amounts of alcohol before starting on this medicine. Your doctor will probably want to order frequent tests to check your body's response to chloroquine. Hydroxychloroquine long term side effects Side effects hydroxychloroquine sulfate 200 mg Mylan hydroxychloroquine 200 mg side effects Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy. Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. UniProt Consortium European Bioinformatics Institute Protein Information Resource SIB Swiss Institute of Bioinformatics UniProt is an ELIXIR core data resource Main funding by National Institutes of Health The European Molecular Biology Laboratory State Secretariat for Education, Research and Innovation SERI Let your healthcare provider know if your symptoms either don't improve or worsen while taking this medicine. Keep all appointments with your doctor and laboratory. Chloroquine target protein Medicines for the Prevention of Malaria While Traveling., Chloroquine Oral Uses, Side Effects, Interactions. Plaquenil and watery eyesPlaquenil tinglingCan plaquenil cause low white blood countHydroxychloroquine sulfate 200 mg To further support our hypothesis we propose that Plasmodium falciparum chloroquine resistance marker protein Pfcrmp may be a CQ target protein in nucleus and that CQ resistance in malaria parasites may be caused by genetic alterations in Pfcrmp gene. Plasmodium falciparum chloroquine resistance marker.. Pfcrt - Chloroquine resistance transporter - Plasmodium.. Chloroquine in Cancer Therapy A Double-Edged Sword of.. Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat. Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, as other mechanisms of resistance are likely. Bioavailability is 89% for tablets. Peak plasma concentration is reached 1.5 to 3 hours after ingestion. Distribution by route of exposure Protein binding 5O to 65%. Chloroquine accumulates in high concentrations in kidney, liver, lung and spleen, and is strongly bound in melanin-containing cells eye and skin. Red cell concentration is five to ten times the plasma concentration.