Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Chloroquine mechanism of action pdf Autofluorescence plaquenil toxicity Guidelines on screening for retinopathy associated with hydroxychloroquine toxicity were initially published by the Academy in 2002. These guidelines were updated in February of this year, given the emergence of more sensitive diagnostic techniques and the recognition that risk of toxicity from years of hydroxychloroquine use is greater than. American Academy of Ophthalmology. The American Academy of Ophthalmology is the largest national membership association of Eye M. D.s. Eye M. D.s are ophthalmologists, medical and osteopathic doctors who provide comprehensive eye care, including medical, surgical and optical care. New American Academy of Ophthalmology recommendations on screening for hydroxychloroquine retinopathy. To the Editor Chloroquine CQ and hydroxychloroquine HCQ are used widely in the treatment of rheumatic disease, and they have the potential to cause serious retinal toxicity when high doses have been taken over a long period of time. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). American academy ophthalmology plaquenil guidelines My Take on New Ocular Screening Guidelines for Plaquenil., American Academy of Ophthalmology Guidelines Pocket Cards & Apps How long to take plaquenil for lupusPlaquenil dizziness Mar 01, 2011 The new guidelines recommend 10-2 automated perimetry, plus at least one of SD-OCT, FAF, or mfERG if they are available. These tests should be performed at baseline and at each subsequent evaluation. Other tests may be considered as well, but are generally insufficiently sensitive to detect early evidence of hydroxychloroquine toxicity. New Screening Guidelines for Hydroxychloroquine Toxicity. New American Academy of Ophthalmology recommendations on.. The 2016 American Academy of Ophthalmology.. Plaquenil toxicity is very distinctive,” said Michael F. Marmor, MD, professor of ophthalmology at Stanford University. Dr. Marmor, who chaired the Academy’s screening guidelines committee, said the goal in Plaquenil screening is to catch changes at a very early stage when there’s just a minimal amount of loss of vision. The American Academy of Ophthalmology released an updated set of screening recommendations for hydroxychloroquine Plaquenil and chloroquine to account for the many studies that have shown the effects of these medications on the retina 1. It succinctly makes the case for screening, and Plaquenil Hydroxychloroquine sulfate is a drug originally used to prevent or treat malaria. Malaria is a serious but rare disease caused by bites from infected mosquitos. Now the drug is used to treat inflammatory diseases. This type of disease occurs when the body's immune system attacks its own healthy tissue.