Retinal thickness parameters as assessed by OCT have been studied extensively in clinical trials, however only modest correlation between these quantitative parameters and visual acuity among a variety of retinal diseases has been established. Advances in OCT technology, most importantly the advent of spectral-domain OCT, have enabled retinal images to be acquired at higher speed and resolution, making it easier to identify boundaries between subtle intraretinal layers In particular, the integrity of the photoreceptor layers as visualized using OCT has been demonstrated to have a more robust correlation with visual acuity than retinal thickness measurements alone, which has drawn attention to the continuity of these layers as possible predictive indicators of visual acuity in a wide variety of ophthalmic diseases that affect the macula. Is plaquenil used to treat osteoarthritis Can chloroquine help rheumatoid arthritis Chloroquin function in lysosome In the outer retinal layers at the level of the IS/OS junction, we noted a focal loss or defect on the nasal and temporal side of the right macula. The left macula exhibited a similar presentation, but the line was not as bold and probably represented diffuse loss. PLAQUENIL should be administered with caution in patients having glucose-6-phosphate dehydrogenase G-6-PD deficiency. Dermatologic Effects Dermatologic reactions to PLAQUENIL may occur and, therefore, proper care should be exercised when it is administered to any patient receiving a drug with a significant tendency to produce dermatitis. Sep 13, 2019 Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. These bands have been extensively studied and their identities have been debated in an attempt to establish terminology that could facilitate communication in the field of ophthalmology. Spectral-domain optical coherence tomography image from the macula of a normal eye. Commercially available SD-OCT instruments have axial resolutions between 4 µm and 7 µm and transverse resolutions of approximately 15 µm, enabling the delineation of four hyper-reflective bands in the outer macula. Plaquenil is os junction Outer Retinal Layers as Predictors of Vision Loss, Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Hydroxychloroquine gh 200 mg Plaquenil retinopathy a Pathophysiology 1 Lysosomal function of RPE affected 2 Phagocytosis of outer segments affected 3 Increased lipufuscin 4 All of this leads to PR an RPE damage, usually in the perifoveal area first 5 Leads to Bull’s Eye maculopathy 2. Contemporary Use of OCT Technology includes Plaquenil. Plaquenil Side Effects Common, Severe, Long Term -. Plaquenil toxicity-eye rounds edited FINAL WARD. Three patients with early HCQ toxicity and HVF 10-2 perifoveal defects were found to have loss of the perifoveal photoreceptor inner segment/outer segment IS/OS junction with intact outer retina. Early loss of the perifoveal photoreceptor IS/OS junction, perifoveal thinning of ONL, and an apparent posterior displacement of inner retinal structures toward the RPE ! Loss of the normal foveal depression + preservation of foveal photoreceptor IS/OS ! “flying saucer” sign. Chen 2010; 9 patients with early toxicity. Concludes that use of SD-OCT Jan 05, 2020 Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported 1.