At first it seemed like it helped now I feel the same as before I started taking the medicine other than the fact that none of my clothes fit and there is a lot more of me to carry around. Anyone know if I quit taking it if the weight will fall back off I started Hydroxychloroquine 2 weeks ago. One week in and I thought this may just work, except for the ‘extra itchiness’ I seemed to get every night. G6pd hydroxychloroquine Chloroquine phosphate mechanism of action Plaquenil is the devil! Worked well 1st 2 mts. After that I had issues with my vision, felt waves of nervousness, and extreme anxiety where I started to question my sanity. Hallucinated, broke out in rashes and crying spells. I don't want to give up breastfeeding but i don't know how long i can go without my meds, especially as i have two older children as well. My rhuematologist believes that there is very little chance that the Plaquenil will harm my son, but i am still nervous. Can anyone tell me their experiences? Thank you Mem Apr 09, 2007 Hi CFS101, I have been on Plaquenil since the beginning of my illness, CFS almost 6 years ago. Funny how it all started. I was a case of sudden onset and also broke out with a rash on my chest and upper back which turned out to be Sub-acute Cutaneous Lupus Erythmatosis skin version of Lupus, not Systemic. I was prescribed this drug to ease my ra disease, I was taking 400mg per day which was to last for 3 months then reduced to 200mg. Right before I hit the two week mark, I woke up with my heart racing and continued feeling my heart flutter all day and I just felt week and tired. After msging Rheum, decided to stop taking meds to see how I feel and continue with the AIP to handle symptoms and try to work at ‘healing from inside out! Time will tell and I’m eager to see how much the AIP is helping once odd meds. Experiences with plaquenil Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Does anyone have experience with Plaquenil. - HealthUnlocked Plaquenil and your eyesPlaquenil dosage for osteoarthritis The aforementioned rare side effect that affects vision hydroxychloroquine retinopathy, if caught early, may improve after discontinuation of Plaquenil. Since the side effect of vision loss is possible but rare, it is important for you to tell your doctor about any vision changes that you experience. Taking Plaquenil for Rheumatoid Arthritis. Experiences with Plaquenil? ProHealth Fibromyalgia, ME/CFS.. Experience with Plaquenil?. I have been taking Plaquenil for just 5 weeks. I started it reluctantly after months of trying diet and acupuncture. I am sticking to the low-lectin diet and monthly acupuncture but in the last 10 days I have noticed a very distinct decrease in my joint pain and swelling and my fatigue has definitely lifted a little. My own experience is that I thought my extreme fatigue was partly from my diagnoses and partly from my methotrexate. I recently saw a surgeon for something unrelated and she indicated, in passing, that she thinks the cause is likely from the plaquenil. I'm getting a hunch that in my case, she may just be right. What are your experiences? Experiences with Plaquenil Hydroxychloroquine? I've recently been referred to a rheumatologist for joint pain arthralgia with a low titre positive ANA. At our first visit she ran tons of blood work/antibody tests only Thyroid Peroxidase Antibodies came back positive and also put me on low dose prednisone for a couple of weeks.