Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Plaquenil and rosacea Chloroquine phosphate degradation Common side effects of plaquenil Malaria prophylaxis with chloroquine Oct 09, 2015 Hi, I have Raynaud's syndrome since 2010, and in 2014 I had a blood test with the result of positive ANA speckled and ACA, ACA-B. I still don't have thickening skin of the hands/fingers, but my doctors told me I have Limited Systemic Scleroderma, since anti centromere antibody ACA is a very specific scleroderma auto-antibody. Immunosuppressants fall under a category of drugs referred to as DMARDs Disease-Modifying Anti-Rheumatic Drugs. ISN. Scleroderma Treatments and Clinical Trials ISN. Effect of disease-modifying anti-rheumatic drugs DMARDs on bone structure and strength in psoriatic arthritis PsA patients. Nonsterodial anti-inflammatory drugs and hydroxychloroquine Plaquenil help both conditions. Most patients with pure schleroderma do not benefit from corticosteroids. Methotrexate, azathioprine, prednisone or cyclophosphamide help lupus and overlap syndromes, and perhaps scleroderma lung disease. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Plaquenil scleraderma Hydroxychloroquine Plaquenil, Disease-Modifying Anti_Rheumatic Drugs DMARDs - Sclero Plaquenil monthsIs chloroquine available over the counter Scleroderma is a rare condition, and patients with scleroderma need specialized care from a rheumatologist familiar with their condition. The care of patients with scleroderma requires a team approach. Many patients with scleroderma will input from different medical specialties including gastroenterology, pulmonary, cardiology, and others. Scleroderma and Systemic Sclerosis SSc An Overview.. Lupus and Scleroderma Overview - Lupus International. Anti-Malarial Medications - Scleroderma News. Scleroderma is a chronic disease that causes abnormal growth of connective tissue. It can affect the joints, skin, and internal organs. It is degenerative and gets worse over time. The disease can be in one area of the body. This is known as localized scleroderma. Or it may affect the whole body. Diagnosis. Because scleroderma can take so many forms and affect so many different areas of the body, it can be difficult to diagnose. After a thorough physical exam, your doctor may suggest blood tests to check for elevated levels of certain antibodies produced by the immune system. See how 938 people just like you are living with scleroderma. Learn from their data and experience. Dismiss this notification PatientsLikeMe would like to remind you that your browser is out of date and many features of the website may not function as expected. Plaquenil Perceived effectiveness.