Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. U87 chloroquine in vivo Weight loss plaquenil Plaquenil side effects insomnia Haemolysis in patients with glucose-6-phosphate dehydrogenase G6PD deficiency, aplastic anaemia, and leukopenia has been reported. The most extensive study to date evaluating G6PD deficiency with concurrent use of hydroxychloroquine reported no episodes of haemolysis in over 700 months of exposure among the 11 studied patients with G6PD. Hydroxychloroquine should be discontinued if ocular toxicity is suspected and patient should be closely observed given that retinal changes and visual disturbances may progress even after cessation of therapy. Hepatic disease or alcoholism. Glucose-6-phosphate dehydrogenase G6PD deficiency is associated with hemolysis and renal impairment. The first Web site established to offer information for G6PD deficient persons. Established in 1995 with the help of the late Ernest Beutler M. D. and the active support of Lucio Luzzatto M. D. Includes official list of drugs to avoid along with trade-names, printable brochure, forum and mailing lists. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine g6pd G6PD Deficiency for Parents - Nemours KidsHealth, Plaquenil hydroxychloroquine sulfate dosing, indications. Reviews on plaquenil If mutations in the G6PD gene reduce the amount of glucose-6-phosphate dehydrogenase or alter its structure, this enzyme can no longer play its protective role. As a result, reactive oxygen species can accumulate and damage red blood cells. Glucose-6-phosphate dehydrogenase deficiency - Genetics Home.. G6PD Deficiency Association - Home. Contraindications for Plaquenil Oral. Rarely, hydroxychloroquine can lead to anemia in some individuals. This can happen in individuals with a condition known as G6PD deficiency or porphyria. In rare cases, hydroxychloroquine can cause visual changes or loss of vision. Such vision problems are more likely to occur in individuals taking high doses for many Among glucose-6-phosphate dehydrogenase-deficient patients with rheumatic disease, hydroxychloroquine was not linked with hemolytic anemia, according to a recently published analysis. There is no data to support the withholding of hydroxychloroquine HCQ therapy among African American patients with glucose-6-phosphate dehydrogenase G6PD, according to the results of a recent review.