Although survival rates have improved, over one half of patients with systemic lupus erythematosus have permanent damage in one or more organ systems. Arthritis and cutaneous manifestations are most common, but renal, hematologic and neurologic manifestations contribute largely to morbidity and mortality. Plaquenil and methotrexate together Is hydroxychloroquine and meloxicam Systemic lupus erythematosus is a disease that continues to evolve over time. Thus, a patient who presents with skin and joint disease remains at risk for renal disease even after having lupus. In 1941, discoid lupus patients were treated successfully with Atabrine, a compound developed in Germany in the 1920s. In the mid-1940s, both hydroxychloroquine HCQ and chloroquine CQ had been synthesized. In 1955 HCQ was shown to be effective for both systemic lupus and rheumatoid arthritis. In active rheumatoid arthritis and systemic and discoid lupus erythematosus, to avoid excessive dosage in obese patients, the daily maximum dose should be calculated on the basis of ideal body weight. Systemic lupus erythematosus has fascinated physicians for almost a century and remains the prototypic autoimmune disease. Treatment approaches emphasize using a combination of drugs to minimize chronic exposure to corticosteroids. Chloroquine for discoid lupus Aralen Chloroquine MyLupusTeam, Drug spotlight on hydroxychloroquine Lupus Foundation of America Plaquenil superamaHydroxychloroquine cheapest priceChloroquine tabletPlaquenil and eyesSickle cell disease hydroxychloroquine Hydroxychloroquine and chloroquine phosphate have shown beneficial effects in treating discoid lupus erythematosus DLE. Additionally, The antimalarial drugs may prevent the development of systemic lupus erythematosus SLE in patients with DLE, and they might decrease the risk of cardiovascular disease. Discoid Lupus Erythematosus Medication Antimalarial agents.. CHLOROQUINE Drug BNF content published by NICE. Discoid Lupus Erythematosus Only Affects Your Skin. Discoid lupus is a chronic autoimmune disease that causes a severe rash on the skin. It gets its name from the coin-shaped lesions it produces. It is well known that isolated lesions of chronic discoid lupus erythematosus may be treated by various local applications, e.g. various acids, solid carbon dioxide, and the intralesional injection of gold compounds. 2,3 Recently, we became interested in the report of Ottolenghi-Lodigiani, 4 on the combined intralesional and oral. Hydroxychloroquine and chloroquine phosphate have shown beneficial effects in treating discoid lupus erythematosus DLE. Additionally, The antimalarial drugs may prevent the development of systemic lupus erythematosus SLE in patients with DLE, and they might decrease the risk of cardiovascular disease. Alternative therapies, anecdotal reports, and small, open-label trials as reported by.