Areas of chloroquine resistant malaria

Discussion in 'Cheap Chloroquine' started by marinak, 18-Mar-2020.

  1. serzh2100 Guest

    Areas of chloroquine resistant malaria


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine resistance is widespread. Chloroquine should not be used for treatment of P. falciparum infections from areas of chloroquine resistance or malaria occurring in patients where chloroquine prophylaxis has failed. Patients infected with a resistant strains of plasmodia should be treated with another antimalarial drug. Travel to areas with chloroquine-resistant malaria Chloroquine-resistant P. falciparum is found in all parts of the world except the Caribbean and countries west of the Panama Canal. Although chloroquine-resistant P. falciparum predominates in Africa, it is found in combination with chloroquine-sensitive P. vivax malaria in South America and Asia. Chloroquine is used extensively in malaria endemic areas in Africa to treat the uncomplicated form of Plasmodium falciparum malaria. However, the efficiency of chloroquine has been severely impacted by the recent development of chloroquine resistant plasmodium falciparum parasites.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Areas of chloroquine resistant malaria

    Chloroquine-Resistant Malaria –, Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health.

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  7. The dramatic impact of chloroquine resistance on malaria mortality has long been underestimated because only a low proportion of malaria attacks are potentially lethal among persons continuously exposed since birth to high levels of transmission. There is an urgent need to change treatment policies in Africa.

    • The Public Health Impact of Chloroquine Resistance in Africa..
    • Chloroquine Resistance in Plasmodium falciparum - microbewiki.
    • Epidemiology of drug-resistant malaria - The Lancet..

    For prophylaxis only in areas with chloroquine-sensitive malaria-Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly same day each week while in malarious areas and for 4 weeks after leaving such areas. Usual Pediatric Dose for Malaria. Infants and children Less than 60 kg Resistant P. vivax was not reported until 1989 in Papua New Guinea 9, although this species accounts for roughly as many cases of malaria as P. falciparum and was exposed to similar high levels of chloroquine pressure. Today, resistant P. vivax is present in several regions of Southeast Asia 10. Resistance to chloroquine, the first widely used antimalarial drug, first arose in the Greater Mekong shortly after World War II. Chloroquine-resistant strains eventually spread to Africa, which carries more than 90 percent of the global malaria burden.

     
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    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Recommendations on Screening for Chloroquine and. Plaquenil Hydroxychloroquine Sulfate Hydroxychloroquine HCQ Arthritis Society
     
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    Chloroquine - Prescription Drug Information, Interactions. Since Chloroquine phosphate tablets are known to concentrate in the liver, it should be used with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs. Central Nervous System Effects Chloroquine may increase the risk of convulsions in patients with a history of epilepsy. Drug Interactions

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