The doctor said that given where I am right now (constant low level pain and light swelling of my hands and wrists but no joint damage showing up on xrays or the ultrasound), she gave me a choice of starting on either Plaquenil or Methotrexate. She went over some info on each drug and then gave me some time to think about which would be better for me. My largest concerns center around the side effects of each... Aralen and food Hydroxychloroquine screening test Does plaquenil treat rhupus Hydroxychloroquine is a prescription drug. It comes as an oral tablet. Hydroxychloroquine is available as the brand-name drug Plaquenil. It’s also available in a generic version. Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral. Oct 09, 2015 I had a biopsy and my doctor said he believes it is morphea. I am waiting on my blood test to come back and he said as soon as it does he will put me on both methotrexate and doctor is a very good derm. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. With Plaquenil, the possibility of permanent vision damage scares me. Plaquenil or methotrexate Compare Methotrexate vs Plaquenil -, Plaquenil hydroxychloroquine sulfate dose, indications. Nivaquine p chloroquine phosphateIs plaquenil compatible with omega 3 fish oil Dosage While in some cases, lower doses of NSAIDS are effective, in rheumatoid arthritis and other forms of inflammatory arthritis a higher dose is often required to decrease inflammation. A lower dosage can initially be used if inflammation is mild, if mechanical pain is the major problem. Rheumatoid Arthritis Treatment Options Johns Hopkins.. Methotrexate and plaquenil - @Kristinsaba1988.. Methotrexate and plaquenil - @Kristinsaba1988 - Scleroderma.. Methotrexate vs plaquenil side effects long term and short term The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. But the Dr suggested I try Methotrexate instead. Hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. The study is based on hydroxychloroquine sulfate and methotrexate sodium the active ingredients of Plaquenil and Methotrexate, respectively. Other drugs that have the same active ingredients e.g. generic drugs or brand names are also considered.