In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. How does hydroxychloroquine work for rheumatoid arthritis Can you take diet pills with plaquenil Chloroquine histamine Protecting your eyesight when taking Plaquenil. With all of the physical and emotional complications that lupus can cause, it’s easy to overlook symptoms that seem minor at first. But take this advice Don’t ignore changes in vision. Aug 14, 2017 Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. One of the most serious side effects is a toxicity in the eye generally with chronic use. People taking 400 mg of hydroxychloroquine or less per day generally have a negligible risk of macular toxicity, whereas the risk begins to go up when a person takes the medication over 5 years or has a cumulative dose of more than 1000 grams. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Eye side effects of plaquenil What Is Plaquenil? - American Academy of Ophthalmology, Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Chloroquine retinopathyMethotrexate vs plaquenil side effects long term Fluoroquinolones are associated with side effects not seen in other classes of antibiotics. Topical administration may cause precipitates in the cornea and, possibly, uveitis. Hepatitis B vaccine may have an association with uveitis. Rx Side Effects New Plaquenil Guidelines and More.. Hydroxychloroquine - Wikipedia. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Eye side effects are serious and can result in loss of vision. The side effects may occur at anytime. The higher the dose and the longer the time of use makes it more likely to occur. This is due to the fact that it accumulates in the pigment cells in the eye over time and dosage level. Aug 29, 2014 This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. The side effect that is of greatest concern is retinal toxicity.