Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Hydroxychloroquine 25mg Chloroquine hyperpigmentation Chloroquine otc Stopping plaquenil before pregnancy Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy the “flying saucer” sign. drug toxicity, hydroxychloroquine, photoreceptors. Normal Spectralis spectral domain optical coherence tomography SD OCT image with intact photoreceptor inner segment/outer segment junction. Previously described OCT findings in HCQ toxicity include loss of the external limiting membrane, disruption of the outer ellipsoid zone, parafoveal thinning of the outer nuclear layer and RPE damage. 6,7,10 Despite these various changes, numerous studies have supported the notion that relative “foveal resistance” is common in HCQ toxicity, as demonstrated by preservation of the subfoveal outer retinal layers, accounting for the intact central visual acuity that can be seen even in. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Oct image plaquenil toxicity Time Domain OCT in Hydroxychloroquine Plaquenil Toxicity - The Retina., Multimodal Imaging in Plaquenil Toxicity Can plaquenil cause a positive nicotine urine test To properly screen patients for Plaquenil toxicity, you should have SD-OCT and automated visual fields; it is also beneficial to include FAF and mfERG. Although the latest guidelines suggest that Amsler grid, color vision and fundus photography are not considered necessary for screening patients on Plaquenil, they can still provide useful information. How to Succeed in Plaquenil Screenings. Plaquenil Side Effects Common, Severe, Long Term -. Spotting the Telltale Signs of Plaquenil Toxicity. OCT scan top of normal macula compared to Plaquenil Toxicity bottom with loss of the outer retinal tissue around the macular center red boxes View more retina images at Retina Rocks, the world’s largest online multimedia retina image library and bibliography repository. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be irreversible. Uploaded on Dec 6, 2016. Last modified by Caroline Bozell on Dec 7, 2016.; Rating Appears in Miscellaneous Condition/keywords plaquenil toxicity Description 70-year-old woman with history of plaquenil use for rheumatoid arthritis.