The doctor said that given where I am right now (constant low level pain and light swelling of my hands and wrists but no joint damage showing up on xrays or the ultrasound), she gave me a choice of starting on either Plaquenil or Methotrexate. She went over some info on each drug and then gave me some time to think about which would be better for me. My largest concerns center around the side effects of each... Chloroquine phosphate site drugs.com Chloroquine resistance in plasmodium vivax Traditional DMARDs. DMARDs are drugs that can help prevent joint damage and deformity from RA. More than a dozen options exist, and they all work by suppressing the immune system. “Methotrexate is the gold standard and is often prescribed to someone with rheumatoid arthritis that has active disease," Dr. Kaplan says. Compare Chloroquine vs Hydroxychloroquine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Chloroquine rated 10.0/10 vs Hydroxychloroquine rated 6.7/10 in overall patient satisfaction. Methotrexate is once a week usually and most of the side effects would hit the next day so some people choose to take it on a Friday or Saturday night and sleep through any potential side effects some people report that caffeine may lower the efficacy of methotrexate, though results have been inconclusive. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. With Plaquenil, the possibility of permanent vision damage scares me. Difference between hydroxychloroquine and methotrexate Common Questions About Taking Methotrexate for Rheumatoid Arthritis, Chloroquine vs Hydroxychloroquine Comparison - Hydroxychloroquine quinineHydroxychloroquine uses in dermatology Methotrexate vs plaquenil side effects long term and short term The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. But the Dr suggested I try Methotrexate instead. Methotrexate vs plaquenil side effects long term and short.. Plaquenil vs Methotrexate rheumatoid. Hydroxychloroquine and nausea Hi it's me again. - NRAS. Original Article from The New England Journal of Medicine — Treatment of Rheumatoid Arthritis with Methotrexate Alone, Sulfasalazine and Hydroxychloroquine, or a Combination of All Three Medications For RA patients, methotrexate is used in a completely different way.” At these extremely lower doses, methotrexate has a completely different effect on the body. It is a disease-modifying agent that reduces inflammation. “I like to say it’s the difference between swimming in a pool and drinking a glass of water. While in some cases, lower doses of NSAIDS are effective, in rheumatoid arthritis and other forms of inflammatory arthritis a higher dose is often required to decrease inflammation. A lower dosage can initially be used if inflammation is mild, if mechanical pain is the major problem.