Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine phosphate powder suicide Plaquenil and ibuprofen Diarrhea difficulty breathing difficulty seeing at night dizziness or fainting fast, pounding, uneven heartbeat feeling that others are watching you or controlling your behavior feeling that others can hear your thoughts feeling, seeing, or hearing things that are not there fever with or without chills Doctors give unbiased, trusted information on whether Hydroxychloroquine can cause or treat Diarrhea Dr. Cattano on plaquenil and diarrhea Temporary GI disturbances are quite common with antibiotics, so a little patience with this understanding comes handy to get the intended benefit from the treatment. Ginny, I had some very minor diarrhea, nausea, cramping for about a week when I started Plaquenil. Everyone is different, but for me, taking the med about 15 min. after eating, rather than before or with a meal, makes things much easier on my stomach, even for just Advil. I do think you should let your rheumy know. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil for diarrhea Plaquenil/ Diarrhea - Autoimmune diseases - Inspire, Plaquenil and diarrhea - Answers on HealthTap Does plaquenil help neuropathy I suspect plaquenil for giving me some episodic diarrhea. I am 100 mg dose and take it with my supper. Did they happen to anyone else and did it eventually stop with the diarrhea side effect? It helps so much with the fatigue and pain. I have a sensitive stomach and perhaps I shouldn't have eaten that salad for lunch yesterday. Plaquenil and diarrhea -. Plaquenil = explosive diarrhea -. Plaquenil and Livalo drug interaction Diarrhea - eHealthMe. I had severe nausea and diarrhea when started on Plaquenil 2 X 200mg tabs once daily almost 3yrs ago. As I also have Crohn's Disease and an Ileostomy this was putting me at serious risk. I was told to stop the Plaquenil until my GI symptoms disappeared. Nausea and diarrhea This can often can be combatted by taking Plaquenil with food or milk. If you experience stomach upset while taking generic hydroxychloroquine, ask your doctor about trying name-brand Plaquenil instead. If you are also taking a certain drug for diarrhea kaolin or taking antacids such as magnesium/aluminum hydroxide, take hydroxychloroquine at least 4 hours before or after these products.