Pharmacological treatment with chloroquine inhibits autophagy in vivo

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  1. IronNem New Member

    Pharmacological treatment with chloroquine inhibits autophagy in vivo


    Several cancer treatments stimulate the autophagic process and when autophagy is inhibited, cancer cells show an enhanced response to multiple treatments. These findings have nourished the theory that autophagy provides cancer cells with a survival advantage during stressful conditions, including exposure to therapeutics.

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    Treatment of cells with the macrolide antibiotic bafilomycin A1, an inhibitor of vacuolar V-ATPase, or with the lysosomotropic agent chloroquine, has been shown to pharmacologically inhibit autophagy as evidenced by an accumulation of autophagosomes, which in turn causes Bax-dependent apoptosis. However, bafilomycin A1 has also been reported to inhibit chloroquine-induced apoptosis. Jun 15, 2014 Resistance to endocrine therapies remains a critical limitation in their ability of these agent to cure some patients. Autophagy is a key pathway in the development of endocrine resistance in breast cancer, and targeting autophagy can reverse antiestrogen resistance 6. Chloroquine, an anti-malarial drug. Pharmacological modulators of this pathway have been extensively utilized in a wide range of basic research and pre-clinical studies. Bafilomycin A1 and chloroquine are commonly used compounds that inhibit autophagy by targeting the lysosomes but through distinct mechanisms.

    In this review we examine two approaches to modulate autophagy as complementary cancer treatment: inhibition and induction. Therefore, interference with the autophagic response can potentially enhance the efficacy of cancer therapy.

    Pharmacological treatment with chloroquine inhibits autophagy in vivo

    Pharmacological Promotion of Autophagy Alleviates., Hydroxychloroquine inhibits autophagy. - PubMed Central PMC

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  7. Similarly, efficacy of mTOR inhibitor, everolimus, and tyrosine kinase inhibitor, gefitinib is enhanced with concurrent treatment of chloroquine compared with single drug administration. CQ derivatives such as Lys-01 and Lys-05 also display anti-tumor effects in adapted cells.

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    Autophagy is a catabolic process through which eukaryotic cells degrade disposable, ectopic or damaged cytoplasmic material. The inhibition or hyperactivation of autophagy has been linked to the. Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation. 1. In the present study, we evaluated the effects of treatment with chloroquine alone, chloroquine + MK2206 or chloroquine + MK2206 + U0126 on cell growth and regrowth of endometriotic stromal cells in vitro. Interestingly, we found no significant difference between U0126 30 μM + MK2206 9 μM + chloroquine 50 μM and MK2206 9 μM + chloroquine 50 μM on either inhibition of cell growth or regrowth after drug discontinuation in DES cells.

     
  8. Web_Ghost Moderator

    In some cases, they may not be available in every strength or form as the brand-name drug. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses DailyMed - PLAQUENIL- hydroxychloroquine sulfate tablet Will you have Diarrhea with Plaquenil - eHealthMe
     
  9. region666 Moderator

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  10. D-o-m-a-i-n-e-r Well-Known Member

    Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more.

    Hydroxychloroquine C18H26ClN3O - PubChem