I have been on plaquenil for about 10 weeks now without much success. I have had the sickness to my stomach and not felt like me including exhausted but it's not as bad as I feared. My hair is coming out slightly Not in clumps are anything, just a little here or there. My doctor said if I don't feel better in a few more weeks, we could switch my medicine. Really though in order not to have worse things happen it is what we have to do. I switched back to cymbalta three days ago and have experienced huge relief. Hydroxychloroquine foods to avoid Chloroquine metabolism No Plaquenil hydroxychloroquine generally takes 6-12 weeks to be effective and can take up to 6 months to reach its maximum benefit. Methotrexate can take 2-3 months and the dose can be increased to as high as 25 mg weekly if lower doses are not adequate.more See 1 more doctor answer Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. It's primarily used to treat IBS but it also works for people who can't take Plaquenil. You might want to discuss it with your doctors. As for the joint pain, often times Plaquenil starts working so gradually that you don't notice how much it's helping until you're off. I was put on methotrexate in 2004 and was only on it 3 months. I did. Vitamin B-12 might help with the hair, ask your doctor about that, well wishes to you and I hope the mtx can help you....((((((((((((((((((((((((((((((((((((((((((((((Jeanneac)))))))))))))))))))))))))))))))))))))))))healing hugz and well wishes and keep us posted on how your doing... Had headaches with the plaquenil so went to the sulfar and predisone. (like i did friday) Take care of yourself and big(((HUGS))) on your journey. He said it would be one that they would have to more closely monitor me on with some blood tests. I was thinking it was methotrexate but I do not want my hair to fall out. It might be coincidence but since on the plaquenil, I have noticed a growth spurt of hair especially at the hairline. Plaquenil made me sick, so I can't take it either, but there are other medicine out there,the doctor's will get you on something that'll help, keep hope..wishes to you and try the methotrexate,to see if it can help... I know it is scary but anything to stop the pain and misfunction of not being able to use my hands or move my knees or not have my ankles cave out and fall. I suspected that I had fibromyalgia on top of the inflammation. I am so relieved but hope I don't start having bad side effects from it like I did before with a very dry mouth and gritting my teeth at night. Can you take methotrexate without plaquenil What is the correct way to discontinue use of plaquenil?, Rheumatoid Arthritis Treatment Options Johns Hopkins. What is plaquenil therapyCan i drink alcohol while taking plaquenilDoes plaquenil make you gain weightSide effects of plaquenil on the eyesWhat is hydroxychloroquine sulfate used for I was on both for 2 years without a problem, I've stopped taking plaquenil but am still on 20mg methotrexate per week for closer to 3 years now without incident. Yes it's scary to begin with but when your quality of life slowly returns it's all worthwhile. Methotrexate and plaquenil - @Kristinsaba1988.. Plaquenil seems to be a "wonder" drug, but I can't take it.. Which would you pick and why? - Plaquenil or Methotrexate. If you can't take Plaquenil. deleted_user 06/18/2012. I've read on these forums that a lot of people take methotrexate. I have been on the plaquinel for a year now and it's been working for me, but you are definitely not alone finding plaquinel doesn't do the job for you. And prednisone is poisonous for me--major high blood pressure and. May 28, 2016 I can't take sulfa drugs so I haven't researched Azulfidene as much as the others, but it seems to be somewhat less commonly used in this community than Plaquenil and Methotrexate. I was started on Plaquenil two months ago and have had zero side effects beyond the very first dose. I take Methotrexate, Plaquenil, hydroxychloroquine Prednisone and Soma. 1 doctor responded Is plaquenil hydroxychloroquine with methotrexate without prednisone an effective treatment for moderate to sev more Is plaquenil hydroxychloroquine with methotrexate without prednisone an effective treatment for moderate to severe rheumatoid.