This medicine is also sometimes given off-label to help the following conditions: Also, let your doctor know if you drink large amounts of alcohol before starting on this medicine. Your doctor will probably want to order frequent tests to check your body's response to chloroquine. Can plaquenil cause a positive nicotine urine test Chloroquine and malaria prophylaxis Plaquenil et soleil Chloroquine was administered to the mice in the first group as 20 mg/kg b.w. once a day for four consecutive days. Quinine at a dose of 20 mg/kg b.w. was given to the mice in the second group for the first day and 10 mg/kg b.w. for the second to fourth day. Malaria treatment oral To treat malaria in adults, one dose of oral chloroquine is usually given right away. Then, half the dose is taken six to eight hours later. This is typically followed by half the dose once a day for the next two days. Amebiasis treatment oral To treat amebiasis in adults. Acute chloroquine poisoning is often fatal; the lethal dose may be as low as 50 mg chloroquine base/kg. Nausea, vomiting and drowsiness, which occur rapidly, are followed by slurring of speech, agitation, visual impairment, breathlessness due to pulmonary oedema, cardiac dysrhythmias, convulsions and coma. Let your healthcare provider know if your symptoms either don't improve or worsen while taking this medicine. Keep all appointments with your doctor and laboratory. Chloroquine lethal dose Chloroquine - FDA prescribing information, side effects and uses, Chloroquine Aralen - Side Effects, Dosage, Interactions. Natural resources to make chloroquineShat needs to be mojitored while on hydroxychloroquine side effectsGluten free plaquenilHydroxychloroquine 400 mg dailyMore energy on plaquenil Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Chloroquine Oral Uses, Side Effects, Interactions.. WHO Model Prescribing Information Drugs Used in Parasitic.. Effects of chloroquine pretreatment on lethal dose of.. Usual Adult Dose for Malaria Prophylaxis. Suppression 400 mg 310 mg base orally on the same day every week Comments-Suppressive therapy should begin 2 weeks prior to exposure; however, failing this, an initial dose of 800 mg 620 mg base may be taken in 2 divided doses 6 hours apart. The therapeutic, toxic and lethal ranges are usually considered to be 0.03 to 15 mg/l, 3.0 to 26 mg/l and 20 to 104 mg/l, respectively. However, nontoxic cases have been reported up to 39 mg/l, suggesting individual tolerance to this agent may be more variable than previously recognised. In one study, serum concentrations of chloroquine appeared to decline in a biphasic manner and the serum half-life of the terminal phase increased with higher dosage of the drug. In this study, the terminal half-life of chloroquine was 3.1 hr after a single 250 mg oral dose, 42.9 hr after a single 500 mg oral dose.