While it comes with a whole host of unpleasant side effects, it has the highest rate of continued long-term treatment. fit=300,270&ssl=1" class="alignleft size-full wp-image-520" src="https://i1com/ resize=300,270&ssl=1" alt="methotrexate" width="300" height="270" data-recalc-dims="1" /However methotrexate is a double edged sword. In short, the side effects are worth it to most people, because it reduces their joint pain and inflammation effectively. Most people who take the drug see it as a necessary evil. Hydroxychloroquine alternatives Side affects hydroxychloroquine Results from a study published in the New England Journal of Medicine have demonstrated that a combination of conventional DMARDs, an approach called “triple therapy” which includes methotrexate, sulfasalazine, and hydroxychloroquine, can provide significant benefits in patients with RA who have. This review analyzes which people have Adverse drug reaction with Hydroxychloroquine sulfate and Sulfasalazine. It is created by eHealthMe based on reports of 1,913 people who have side effects when taking Hydroxychloroquine sulfate and Sulfasalazine from Food and Drug Administration FDA, and is updated regularly. Hi, I was diagnosed with RA and was put on sulfa, my rheumy tried adding mtx but i had awful side effects so am now on hydroxychloroquine and sulfa.this combination worked for anyone? just. The body can adjust, particularly if the drug dose is tapered up slowly. Some people don’t experience side effects at all, but most experience some discomfort at least. For most people, the side effects will fade over time. Hydroxychloroquine and sulfasalazine combination Plaquenil hydroxychloroquine sulfate dose, indications., Hydroxychloroquine sulfate and Sulfasalazine drug interaction. Lyrica and hydroxychloroquinePlaquenil weight gain loss Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in. Rheumatoid Arthritis Treatment Options Johns Hopkins.. Combination hydroxychloroquine and sulfasalazine - HealthUnlocked. Hydroxychloroquine Uses, Dosage & Side Effects -. O’Dell JR et al. 2002 “Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications results of a two-year, randomized, double-blind, placebo-controlled trial” Arthritis Rheum May;4651164-70. If one or two medications are not enough, doctors can turn to triple therapy. The most common combination is methotrexate, sulfasalazine and hydroxychloroquine. Research shows that in some cases, using three conventional DMARDs together is just as effective as using a DMARD in combination with a biologic drug. Early, aggressive disease management is critical for halting disease progression and joint destruction in patients with rheumatoid arthritis. Combination therapy with at least two disease-modifying antirheumatic drugs, such as methotrexate MTX, sulfasalazine, or hydroxychloroquine, is often more effective than monotherapy in reducing disease.